What is the purpose of this test?
Order this Zonulin Family Peptide Add-On - Genova Test Kit, which measures zonulin levels in the gut, to help diagnose the condition known as "Leaky Gut Syndrome" by indicating the extent of intestinal permeability. Zonulin is a protein molecule that plays a role in regulating the tight junctions in the intestinal wall. When it binds to specific receptors on cell surfaces, it causes the tight junctions to open up, which increases intestinal permeability. This can be caused by exposure to certain types of bacteria. Exposure to foreign antigens and cell components can lead to immunological reactions and dysregulations. High levels of Zonulin are typically observed in people with Type 1 Diabetes, autoimmune diseases, celiac disease, multiple sclerosis, rheumatoid arthritis, and other chronic conditions.
Reducing the intake of simple sugars, sodium, emulsifiers, and nano-particles can improve gut health. To restore the mucosal barrier, take digestive and anti-inflammatory supplements like quercetin, vitamin C, curcumin, EPA, DHA, and aloe vera. Zinc, beta-carotene, pantothenic acid, and L-glutamine are also helpful. Probiotics and inulin can help lower zonulin levels.
This ZFP test is useful for individuals with the underlying conditions:
- Celiac disease
- Non-celiac gluten sensitivity
- Type I diabetes
- Juvenile nonalcoholic fatty liver disease
- Multiple sclerosis
- Rheumatoid arthritis
- Asthma
- Inflammatory bowel disease
- Adult glucose intolerance
Individuals should note that this test kit is only offered as an add-on test for the following Genova Diagnostics test kits:
- Gastrointestinal (GI) Effects Comprehensive Stool Profile 1-Day Test Kit (GD2200)
- Gastrointestinal (GI) Effects Comprehensive Stool Profile 3-Day Test Kit (GD2201)
- Gastrointestinal (GI) Effects Microbial Ecology Stool Profile (GD2205)
- Gastrointestinal (GI) Effects Fundamentals Stool Profile (GD2209)
Don't hesitate to contact Walk-In Lab's Customer Service at 1-800-539-6119 if you are interested in this add-on test, as additional charges will be applied.
Preparation:
Ship test kits to the lab Monday-Thursday only. No fasting is required for collection. However, before collecting a sample for fat absorption assessment, patients should consume their normal dietary fat intake. It is recommended to wait at least two weeks after completing medications such as PPIs, bismuth, antifungals, antibiotics, probiotics, and anti-parasitics. Patients should avoid taking digestive enzymes, laxatives (particularly mineral or castor oil), antacids, aspirin, and substances containing barium or bismuth for at least 48 hours before and during specimen collection. Consult with your physician before stopping any medications.
Test Results:
14 business days once the lab receives the specimen. May take longer based on weather, holiday, or lab delays.
