What is the purpose of this test?
Order this SNP TNFA Buccal Swab Add-On - Genova Test Kit, which detects the TNF-α gene in a cheek sample to identify the causes of chronic inflammation. Cytokines are tiny signals the body makes when the immune system works. They help balance the immune system, control inflammation, and fight diseases. Cytokines work quickly, but only for a short time and in small amounts. They attach to specific parts of cells and tell them what to do. Cytokines can help or hurt the body, and they can cause other cytokines to be made. Sometimes they work together, and sometimes they work against each other.
Tumor necrosis factor-alpha (TNF-α) is a cytokine found in our body that helps fight infections and can also cause inflammation and cell death. Too much of it in one spot can make that area hot, swollen, red, painful, and not work right. Scientists discovered that TNF-α can also kill tumors in people with certain infections. Special medicines called biologics can help with diseases caused by too much TNF-α. TNF-α can also help balance our immune system by limiting inflammation and fighting off harmful germs.
When there are too many TNF-α in the body, it can cause a severe medical condition called septic shock. TNF-α has also been linked to the development of asthma and atopic dermatitis. People with systemic mastocytosis may have a lot of TNF-α in their blood. During the acute phase, highly elevated histamine and cytokine concentrations are often found together, suggesting that they come from the same type of cells, which are likely activated mast cells. TNF-α levels are also high in hospitalized patients with acute lung injury.
When should I order a SNP TNFA Buccal Swab Add-On - Genova Test Kit?
Individuals may order this add-on test if they have experienced chronic or acute inflammatory responses, such as the following conditions:
- Asthma
- Autoimmune Disorders
- Certain Cancers
- Allergy
- Infectious Diseases
- Bone Inflammation
- Arthritis
- Inflammatory Bowel Disease
- Heart Disease
- Osteopenia
- Helicobacter pylori infection (cause of ulcers)
Preparation:
Fasting for at least 10-12 hours is required. Ship to lab Monday-Thursday only. Please read the directions and collection procedures before starting the test.
Test Results:
14 days once the lab receives the specimen. May take longer based on weather, holiday, or lab delays.
