Nicotine and Expanded Metabolites, LC/MS/MS, Urine Test

What is the purpose of this test?

The Nicotine and Expanded Metabolites, LC/MS/MS, Urine Test is a specialized test that measures nicotine and several nicotine metabolites in your urine using advanced liquid chromatography-tandem mass spectrometry (LC/MS/MS). This test helps detect both recent and long-term exposure to nicotine from smoking, vaping, or using nicotine replacement products. It can also identify secondhand smoke exposure, which is especially important in households with children or individuals with asthma or other lung conditions.

This expanded test offers more in-depth information than basic nicotine tests. By checking for multiple nicotine breakdown products,it helps doctors and health professionals understand the extent and pattern of nicotine use. It can also help in smoking cessation programs, substance use evaluations, and clinical studies. Because it detects additional metabolites, this test can also distinguish tobacco use from nicotine replacement therapy, giving clearer answers for treatment planning or monitoring.

The Nicotine and Expanded Metabolites, LC/MS/MS, Urine Test includes:

• Nicotine: The main active ingredient in tobacco, showing recent use or exposure.
• Cotinine: The primary substance made when your body breaks down nicotine; used to detect nicotine exposure over a longer time.
• 3-OH-Cotinine: A major cotinine metabolite that helps determine how quickly your body processes nicotine.
• Nornicotine: A minor nicotine breakdown product that supports identifying tobacco use.
• Norcotinine: Another metabolite helping to track nicotine metabolism in the body.
• Anabasine: A tobacco-specific compound not found in nicotine replacement products; helps tell if someone is using tobacco instead of just nicotine patches or gum.

Who should get this test?

• Individuals trying to quit smoking or vaping who want to monitor their progress
• Healthcare providers monitoring nicotine replacement therapy
• People who may have been exposed to secondhand smoke
• Employers or legal agencies conducting nicotine screening
• Researchers studying tobacco use or exposure
• Parents or guardians concerned about teen nicotine use
• Anyone needing a more detailed nicotine exposure test than basic screenings

When should I order the Nicotine and Expanded Metabolites, LC/MS/MS, Urine Test?

Individuals may consider ordering this test if they have symptoms or exposure concerns related to nicotine or tobacco products.

Symptoms to consider:

• Headaches, dizziness, or nausea after being around smokers
• Difficulty breathing or a lingering cough not caused by illness
• Chest tightness or wheezing in children or adults
• Nervousness, anxiety, or restlessness related to nicotine withdrawal
• Increased heart rate or blood pressure
• Yellowing fingers or teeth, which may signal smoking

If you have these symptoms or suspect nicotine exposure, the Nicotine and Expanded Metabolites, LC/MS/MS, Urine Test can help provide clear answers to guide you and your healthcare provider in improving your health and reducing risks.