Gliadin (Deamidated) Antibody Profile Blood Test, IgA and IgG

What is the purpose of this test?

The Gliadin (Deamidated) Antibody Profile Blood Test, IgA and IgG, helps check for antibodies in your blood that may suggest an immune response to gluten. Gluten is a protein found in wheat, barley, and rye. In some people, the immune system reacts abnormally to gluten, leading to conditions like celiac disease or gluten sensitivity. This test looks for two specific types of antibodies: IgA and IgG. The IgA antibody is usually found in high levels in people with active celiac disease, while the IgG antibody can indicate gluten sensitivity or immune response even if IgA levels are normal. Measuring both antibodies provides a clearer picture of how your immune system is responding to gluten.

This test is particularly important for identifying celiac disease, an autoimmune condition where gluten consumption triggers the immune system to attack the small intestine. Damage to the intestine can cause nutrient malabsorption, leading to fatigue, weight loss, and other health issues. The test can also help detect non-celiac gluten sensitivity, which causes symptoms similar to celiac disease but without intestinal damage. Early detection of gluten-related conditions can help guide dietary changes and prevent further health complications.

Who should get this test?

• Individuals experiencing digestive issues such as bloating, diarrhea, or constipation after eating gluten.
• People with unexplained fatigue, joint pain, or skin problems.
• Individuals with a family history of celiac disease or gluten sensitivity.
• Those who have nutrient deficiencies despite a balanced diet.
• People who have unexplained weight loss or difficulty gaining weight.
• Individuals who suspect gluten is causing health issues but are unsure.

When should I order the Gliadin (Deamidated) Antibody Profile Blood Test, IgA and IgG?

Individuals may consider ordering this test if they have symptoms or exposure concerns related to gluten intolerance or celiac disease. Symptoms to consider:

• Frequent bloating, gas, or stomach pain after eating gluten-containing foods.
• Chronic diarrhea or constipation without a clear cause.
• Unexplained weight loss or slow weight gain.
• Skin rashes, particularly itchy and blistering types like dermatitis herpetiformis.
• Ongoing fatigue or low energy levels.
• Joint pain or muscle weakness without an obvious injury.

If you have these symptoms or suspect gluten may be affecting your health, the Gliadin (Deamidated) Antibody Profile Blood Test, IgA and IgG, can provide helpful information to guide you and your doctor in managing your health and exploring gluten-free dietary changes.