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Creatine Kinase Isoenzymes (CK Isoenzymes) Blood Test without Total CK

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A CK Isoenzymes Blood Test without Total CK is useful in locating damage to muscles in your body, including heart, brain, and skeletal muscle.

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CPK isoenzyme testing can help find the exact source of the damaged tissue.

CPK is made up of three slightly different substances:

CPK-1 (also called CPK-BB) is found mostly in the brain and lungs
CPK-2 (also called CPK-MB) is found mostly in the heart
CPK-3 (also called CPK-MM) is found mostly in skeletal muscle

Higher-than-normal CPK-1 levels:

Because CPK-1 is found mostly in the brain and lungs, injury to either of these areas can increase CPK-1 levels. Increased CPK-1 levels may be due to:

Brain cancer
Brain injury (due to any type of injury including, stroke, or bleeding in the brain)
Electroconvulsive therapy
Pulmonary infarction
Seizure

Higher-than-normal CPK-2 levels:

CPK-2 levels rise 3 to 6 hours after a heart attack. If there is no further heart muscle damage, the level peaks at 12 to 24 hours and returns to normal 12 to 48 hours after tissue death.

Increased CPK-2 levels may also be due to:

Electrical injuries
Heart defibrillation (purposeful shocking of the heart by medical personnel)
Heart injury (for instance, from a car accident)
Inflammation of the heart muscle usually due to a virus (myocarditis)
Open heart surgery

Higher-than-normal CPK-3 levels are most often a sign of muscle injury or muscle stress. They may be due to:

Crush injuries
Muscle damage due to drugs or being immobile for a long time (rhabdomyolysis)
Muscular dystrophy
Myositis (skeletal muscle inflammation)
Receiving many intramuscular injections
Recent nerve and muscle function testing (electromyography)
Recent seizures
Recent surgery
Strenuous exercise

Intense physical exercise, such as running a marathon, within a day or two of the test can lead to higher CK-MB levels.

Skeletal muscle damage, especially blunt trauma to the muscles, and cocaine abuse can also increase your levels of CK-MB. CK-MB is found mostly in the heart.

Drinking too much alcohol can also raise your CK levels. In some cases, people with low thyroid hormone levels, kidney failure, or alcohol abuse may also have higher CK-MB levels.

Drugs that can increase CPK measurements include the following:

Alcohol
Amphotericin B
Certain anesthetics
Cocaine
Fibrate drugs
Statins
Steroids, such as dexamethasone

This list is not all-inclusive

This test does not include Total CK.

Sample Report

Test Code(s):

377

Also Known As:

CPK Isoenzymes

Specimen:

Blood

Preparation:

No special preparation required.

Test Results:

3-5 days. May take longer based on weather, holiday or lab delays.

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