What is the purpose of this test?
The ALCAT Add-On CICA: Antibody Only Test Kit is designed to identify the presence of antibodies in the blood that may be causing gastrointestinal (GI) issues in individuals. GI issues are prevalent in the United States, affecting millions of people and causing discomfort, pain, and disruption of daily activities. The symptoms of GI issues can vary widely, and it can be difficult to diagnose the root cause of the problem.
The ALCAT Add-On CICA: Antibody Only Test Kit can benefit individuals with GI issues by providing a non-invasive and comprehensive way to identify which foods and substances may be causing an immune response in their bodies. By identifying these triggers, individuals can make informed decisions about their diet and lifestyle to manage their symptoms more effectively. This test kit is particularly useful for people with food sensitivities, allergies, and intolerances, as well as those with conditions such as Irritable Bowel Syndrome (IBS), Crohn's disease, and Ulcerative Colitis.
Overall, the ALCAT Add-On CICA: Antibody Only Test Kit is a valuable tool for anyone experiencing GI issues, as it can help identify potential triggers and provide personalized recommendations for managing symptoms and improving overall quality of life.
The CICA: Antibody Only, Add-On Test - ALCAT Test Kit includes the following:
- Tissue transglutaminase antibody (tTG) – IgA & IgG - In active celiac disease, damaged enterocytes produce tTG; therefore, antibodies against tTG (IgA and/or IgG) are indicative of an active disease process. In patients with normal total IgA levels and negative tTG antibodies, the diagnosis of active celiac disease is unlikely. However, a certain percentage of patients with celiac disease may be seronegative. If tTG IgA is negative, while celiac disease is suspected, then additional markers included in this panel become more relevant in the diagnosis of gluten-related disorders.
- Deamidated gliadin peptide (DGP) antibody - IgA & IgG - Deamidated gliadin can bind with tTG and become immunogenic. Therefore, detecting the presence of elevated IgA and/or IgG antibodies against DGP is an additional indicator of an active celiac disease process.
- Anti-Saccharomyces Cerevisiae Antibody (ASCA) - IgA & IgG - ASCA is an indicator for the presence of Crohn's disease. The presence of ASCA may also reflect increased intestinal inflammation and permeability, including that associated with active celiac disease.
- Total Serum IgA - It is common for celiac disease patients to be IgA deficient. It is the most common immunologic deficiency (1:400-1:700 in the general population and 1:50 in celiac disease patients) and may be the single largest contributor to false negative results in biopsy confirmed celiac disease patients. Total Serum IgA is used as a measurement to qualify IgA testing for tissue transglutaminase (tTG) and deaminated gliadin peptide (DGP) antibody levels. When IgA levels are low or deficient, it is important to check IgG levels for both tTG and DGP (included in this array).
Who would benefit from this CICA: Antibody Only, Add-On Test - ALCAT Test Kit?
- Those with gastrointestinal symptoms and autoimmune disorders that might suggest a problem with gluten
- Those with increased intestinal permeability, which has been linked to autoimmune disorders and other conditions
- Those suspected to have Crohn's or celiac disease
- Those suffering from symptoms of IBS, including diarrhea, bloating, or cramping
- Those with chronic fatigue
- Those with malabsorption of nutrients or iron deficiency
Preparation:
No fasting is required.
Test Results:
7-10 business days once the lab receives the specimen. May take longer based on weather, holiday, or lab delays.
