The aldosterone-renin activity ratio blood test is used to detect excess or deficiency in aldosterone and renin levels and to help diagnose primary aldosteronism (PA, also known as Conn syndrome). This test looks at the ratio between these two hormones to help make that diagnosis.
Aldosterone is a hormone that plays an essential part in keeping normal sodium and potassium levels in the blood and in controlling blood pressure and blood volume. High levels of aldosterone can result from primary aldosteronism (PA), which causes high blood pressure. Elevated levels can cause a variety of other health conditions.
Renin is an enzyme that is produced by the kidneys, which stimulates the production of aldosterone by the adrenal glands. When there is a fall in blood pressure, or when the sodium level in the blood is lower than normal, the production of renin is triggered.
Symptoms of aldosterone excess (hyperaldosteronism), possibly caused by high levels of sodium and low levels of potassium in the blood, may include:
- Muscle weakness
- High blood pressure
- Headache
Symptoms of aldosterone deficiency, including low blood pressure, possibly caused by low blood sodium levels and high blood potassium levels, could be classified as part of a condition called adrenal insufficiency. Other symptoms of this condition may include:
- Dehydration
- Weakness
- Low blood glucose
- Joint pain
- Bellyaches
- Dark skin patches
LC Sample ReportQD Sample Report
Test Code(s):
004354, 16845
Also Known As:
Aldosterone-renin ratio (ARR); Aldosterone and Plasma Renin Activity; PRA; ARR
Preparation:
No fasting required. If possible, medications should be stopped 4 weeks prior to collection. Check with physician before stopping any medications. Collection should be performed mid morning, after the patient has been up (sitting, standing, or walking) for at least two hours and seated for 5 to 15 minutes prior to draw. Do not drink coffee, tea, or cola during the day the blood is collected. Certain medications, such as NSAID pain relievers (like ibuprofen), steroids, diuretics, beta-blockers, angiotensin-converting enzyme inhibitors, oral contraceptives, and dietary salt, may affect the results. Check with physician before stopping any medications.
Test Results:
4-7 days. May take longer based on weather, holiday or lab delays.
